| 产品编号 |
bs-46108P |
| 英文名称 |
Recombinant SARS-Cov-2 Spike protein fragment, N-His
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| 中文名称 |
重组SARS冠状病毒2Spike 蛋白 |
| 别 名 |
Spike glycoprotein;Spike protein; Recombinant SARS-Cov-2 Spike protein fragment 2 protein, N-His 新冠病毒S蛋白; 新冠S蛋白; 新冠S2蛋白; SARS-CoV-2 S2蛋白; |
| 克 隆 号 |
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| 理论分子量 |
17 kDa |
| 检测分子量 |
20 |
| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
＞0.5 mg/ml |
| 物 种 |
SARS-Cov-2 |
| 序 列 |
1047-1201/1273 |
| 纯 度 |
>95% as determined by SDS-PAGE |
| 纯化方法 |
AC |
| 内毒素 |
Not analyzed |
| 表达系统 |
E.coli |
| 活性 |
Not tested |
| 标签 |
N-His |
| 缓 冲 液 |
Supplied as solution form in PBS (pH7.5) with 0.02% NLS. |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
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| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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